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1

Clinical Implications of Pathophysiological and Demographic Covariates on the Population Pharmacokinetics of Trastuzumab Emtansine, a HER2-Targeted Antibody-Drug Conjugate, in Patients With HER2-Positive Metastatic Breast Cancer

Gupta, Manish, LoRusso, Patricia M., Wang, Bei, Yi, Joo-Hee, Burris, Howard A., Beeram, Muralidhar, Modi, Shanu, Chu, Yu-Waye, Agresta, Samuel, Klencke, Barbara, Joshi, Amita, Girish, Sandhya

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 2.02 MB

english, 2012

2

A phase I pharmacokinetic and safety evaluation of oral pazopanib dosing administered as crushed tablet or oral suspension in patients with advanced solid tumors

Elisabeth I. Heath, Karen Forman, Lisa Malburg, Shelby Gainer, A. Benjamin Suttle, Laurel Adams, Howard Ball, Patricia LoRusso

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 219 KB

english, 2012

3

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

Von Hoff, Daniel D., LoRusso, Patricia M., Rudin, Charles M., Reddy, Josina C., Yauch, Robert L., Tibes, Raoul, Weiss, Glen J., Borad, Mitesh J., Hann, Christine L., Brahmer, Julie R., Mackey, Howard

Journal:

Boston Medical and Surgical Journal

Year:

2009

Language:

english

File:

PDF, 654 KB

english, 2009

4

Erlotinib therapy for central nervous system hemangioblastomatosis associated with von Hippel-Lindau disease: a case report

Lisa R. Rogers, Patricia LoRusso, Paul Nadler, Ghaus Malik, Anthony Shields, William Kaelin

Journal:

Journal of Neuro-Oncology

Year:

2011

Language:

english

File:

PDF, 132 KB

english, 2011

5

Controlled-release oxycodone compared with controlled-release morphine in the treatment of cancer pain: a randomized, double-blind, parallel-group study

Patricia Mucci-LoRusso, Barry S. Berman, Peter T. Silberstein, Marc L. Citron, Linda Bressler, Sharon M. Weinstein, Robert F. Kaiko, Barbara J. Buckley, Robert F. Reder

Journal:

European Journal of Pain

Year:

1998

Language:

english

File:

PDF, 1.14 MB

english, 1998

6

Phase I study of liposomal doxorubicin (Doxil) and cyclophosphamide in solid tumors

Basil F. El-Rayes, Dina Ibrahim, Anthony F. Shields, Patricia M. LoRusso, Mark M. Zalupski, Philip A. Philip

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 59 KB

english, 2005

7

Clinical experience of MEK inhibitors in cancer therapy

Ding Wang, Scott A. Boerner, James D. Winkler, Patricia M. LoRusso

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2007

Language:

english

File:

PDF, 207 KB

english, 2007

8

Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial

Krop, Ian E, Kim, Sung-Bae, González-Martín, Antonio, LoRusso, Patricia M, Ferrero, Jean-Marc, Smitt, Melanie, Yu, Ron, Leung, Abraham C F, Wildiers, Hans

Journal:

The Lancet Oncology

Year:

2014

Language:

english

File:

PDF, 422 KB

english, 2014

9

Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer

McLaughlin, Joseph, Han, Gang, Schalper, Kurt A., Carvajal-Hausdorf, Daniel, Pelekanou, Vasiliki, Rehman, Jamaal, Velcheti, Vamsidhar, Herbst, Roy, LoRusso, Patricia, Rimm, David L.

Journal:

Year:

2015

Language:

english

File:

PDF, 644 KB

english, 2015

10

Trastuzumab Emtansine (T-DM1) in Patients With HER2-Positive Metastatic Breast Cancer Previously Treated With Chemotherapy and 2 or More HER2-Targeted Agents

Yardley, Denise A., Krop, Ian E., LoRusso, Patricia M., Mayer, Musa, Barnett, Brian, Yoo, Bongin, Perez, Edith A.

Journal:

The Cancer Journal

Year:

2015

Language:

english

File:

PDF, 172 KB

english, 2015

11

Qualitative Analysis of the Experience of Mental Fatigue of Family Caregivers of Patients With Cancer in Phase I Trials

Weiss, Denise, Northouse, Laurel, Duffy, Sonia, Ingersoll-Dayton, Berit, Katapodi, Maria, LoRusso, Patricia

Journal:

Oncology Nursing Forum

Year:

2016

Language:

english

File:

PDF, 133 KB

english, 2016

12

Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor–related protein agonist AMG 228 in patients with advanced solid tumors

Tran, Ben, Carvajal, Richard D., Marabelle, Aurelien, Patel, Sandip Pravin, LoRusso, Patricia M., Rasmussen, Erik, Juan, Gloria, Upreti, Vijay V., Beers, Courtney, Ngarmchamnanrith, Gataree, Schöffski

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2018

Language:

english

File:

PDF, 2.49 MB

english, 2018

13

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study

Munster, Pamela, Krop, Ian E., LoRusso, Patricia, Ma, Cynthia, Siegel, Barry A., Shields, Anthony F., Molnár, István, Wickham, Thomas J., Reynolds, Joseph, Campbell, Karen, Hendriks, Bart S., Adiwijay

Journal:

British Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 1.17 MB

english, 2018

14

Improving Attribution of Adverse Events in Oncology Clinical Trials

George, Goldy C., Barata, Pedro C., Campbell, Alicyn, Chen, Alice, Cortes, Jorge E., Hyman, David M., Jones, Lee, Karagiannis, Thomas, Klaar, Sigrid, Le-Rademacher, Jennifer G., LoRusso, Patricia, Man

Journal:

Cancer Treatment Reviews

Year:

2019

Language:

english

File:

PDF, 828 KB

english, 2019

15

Levels of 5-hydroxymethyl-2′-deoxyuridine in DNA from blood as a marker of breast cancer

Zora Djuric, Lance K. Heilbrun, Michael S. Simon, Daryn Smith, Domenico A. Luongo, Patricia M. LoRusso, Silvana Martino

Journal:

Year:

1996

Language:

english

File:

PDF, 565 KB

english, 1996

16

Chemotherapy for paranasal sinus carcinoma. A 10-year experience at Wayne state university

Patricia Lorusso, Efstathios Tapazoglou, Julie A. Kish, John F. Ensley, Glenn Cummings, John Kelly, Muhyi Al-Sarraf

Journal:

Year:

1988

Language:

english

File:

PDF, 534 KB

english, 1988

17

A phase II study of bortezomib in the treatment of metastatic malignant melanoma

Svetomir N. Markovic, Susan M. Geyer, Fitzroy Dawkins, William Sharfman, Mark Albertini, William Maples, Paula M. Fracasso, Tom Fitch, Patricia LoRusso, Alex A. Adjei, Charles Erlichman

Journal:

Year:

2005

Language:

english

File:

PDF, 86 KB

english, 2005

18

Simultaneous determination of ABT-888, a poly (ADP-ribose) polymerase inhibitor, and its metabolite in human plasma by liquid chromatography/tandem mass spectrometry

Richard Wiegand, Jianmei Wu, Xianyi Sha, Patricia LoRusso, Jing Li

Journal:

Journal of Chromatography B

Year:

2010

Language:

english

File:

PDF, 435 KB

english, 2010

19

Validation and implementation of a liquid chromatography/tandem mass spectrometry assay for quantitation of the total and unbound RO4929097, a γ-secretase inhibitor targeting Notch signaling, in human plasma

Jianmei Wu, Richard Wiegand, Patricia LoRusso, Jing Li

Journal:

Journal of Chromatography B

Year:

2011

Language:

english

File:

PDF, 548 KB

english, 2011

20

Capecitabine and PPE Syndrome: A Case Report

Patricia M. LoRusso

Journal:

The Breast Journal

Year:

2003

Language:

english

File:

PDF, 55 KB

english, 2003

21

Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice

Patricia Mucci-LoRusso, Lisa Polin, Laura A. Biernat, Frederick A. Valeriote, Thomas H. Corbett

Journal:

Investigational New Drugs

Year:

1990

Language:

english

File:

PDF, 671 KB

english, 1990

22

Activity of batracylin (NSC-320846) against solid tumors of mice

Patricia Mucci-LoRusso, Lisa Polin, Marie-Christine Bissery, Frederick Valeriote, Jacqueline Plowman, Gordon D. Luk, Thomas H. Corbettv

Journal:

Investigational New Drugs

Year:

1989

Language:

english

File:

PDF, 882 KB

english, 1989

23

5-Fluorouracil containing combinations in murine tumor systems

Thomas H. Corbett, Marie-Christine Bissery, Patricia Mucci-LoRusso, Lisa Polin

Journal:

Investigational New Drugs

Year:

1989

Language:

english

File:

PDF, 956 KB

english, 1989

24

Preclinical antitumor activity of CI-994

Patricia Mucci LoRusso, Lisa Demchik, Brenda Foster, Juiwanna Knight, Marie-Christine Bissery, Lisa Marie Polin, Wilbur R. Leopold, Thomas H. Corbett

Journal:

Investigational New Drugs

Year:

1996

Language:

english

File:

PDF, 660 KB

english, 1996

25

Phase I trial of Adozelesin using the treatment schedule of daily × 5 every 3 weeks

Brenda J. Foster, Patricia M. LoRusso, Elizabeth Poplin, Mark Zalupski, Manuel Valdivieso, Antoinette Wozniak, Lawrence Flaherty, Dorothy A. Kasunic, Robert H. Earhart, Laurence H. Baker

Journal:

Investigational New Drugs

Year:

1995-1996

Language:

english

File:

PDF, 525 KB

english, 1995-1996

26

Comparative efficacy of DMP 840 against mouse and human solid tumor models

Patricia LoRusso, Lisa Demchik, Maria Dan, Lisa Polin, Janet L. Gross, Thomas H. Corbett

Journal:

Investigational New Drugs

Year:

1995

Language:

english

File:

PDF, 731 KB

english, 1995

27

In vitro and in vivo effects of acetyldinaline on murine megakaryocytopoiesis

Donna A. Volpe, Patricia M. LoRusso, Brenda J. Foster, Ralph E. Parchment

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2004

Language:

english

File:

PDF, 230 KB

english, 2004

28

Bioavailability and pharmacokinetics of the investigational anticancer agent XK469 (NSC 698215) in rats following oral and intravenous administration

Ramesh R. Boinpally, Sen-Lin Zhou, Patricia M. LoRusso, Ralph E. Parchment

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 239 KB

english, 2005

29

Metabolic profile of XK469 (2(R)-[4-(7-chloro-2-quinoxalinyl)oxyphenoxy]-propionic acid; NSC698215) in patients and in vitro: low potential for active or toxic metabolites or for drug–drug interactions

Lawrence W. Anderson, Jerry M. Collins, Raymond W. Klecker, Aspandiar G. Katki, Ralph E. Parchment, Ramesh R. Boinpally, Patricia M. LoRusso, S. Percy Ivy

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 253 KB

english, 2005

30

4,4′-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007): a topical treatment for cutaneous metastases from malignant cancers

David Eilender, Patricia LoRusso, Leonard Thomas, Catherine McCormick, Andrew H. Rodgers, Catherine L. Hooper, Karl Tornyos, Edward T. Krementz, Steven Parker, Lee Roy Morgan

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2006

Language:

english

File:

PDF, 327 KB

english, 2006

31

Sunitinib in combination with paclitaxel plus carboplatin in patients with advanced solid tumors: phase I study results

Elisabeth I. Heath, George R. Blumenschein, Roger B. Cohen, Patricia M. LoRusso, Noelle K. LoConte, Sindy T. Kim, Ana Ruiz-Garcia, Richard C. Chao, George Wilding

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 210 KB

english, 2011

32

Lack of food effect on single-dose pharmacokinetics of brivanib, and safety and efficacy following multiple doses in subjects with advanced or metastatic solid tumors

Patricia LoRusso, Geoffrey I. Shapiro, Herbert Hurwitz, Mary Jo Pilat, Janice Chemidlin, Georgia Kollia, Shariq Syed, Bruce Fischer, Eric Masson

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 333 KB

english, 2011

33

Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study

Ticiana B. Leal, Scot C. Remick, Chris H. Takimoto, Ramesh K. Ramanathan, Angela Davies, Merrill J. Egorin, Anne Hamilton, Patricia A. LoRusso, Stephen Shibata, Heinz-Josef Lenz, James Mier, John Sara

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 397 KB

english, 2011

34

Phase II study of pyrazoloacridine in patients with advanced colorectal carcinoma

Mark M. Zalupski, Philip A. Philip, Patricia LoRusso, Anthony F. Shields

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 101 KB

english, 1997

35

Phase II study of CI-958 in colorectal cancer

Anthony F. Shields, Philip A. Philip, Patricia M. LoRusso, Ann M. Ferris, Mark M. Zalupski

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 67 KB

english, 1999

36

A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancer

Elaina M. Gartner, Paula Silverman, Michael Simon, Lawrence Flaherty, Judith Abrams, Percy Ivy, Patricia M. LoRusso

Journal:

Breast Cancer Research and Treatment

Year:

2012

Language:

english

File:

PDF, 157 KB

english, 2012

37

A phase I study of flavopiridol and docetaxel

Basil F. El-Rayes, Shirish Gadgeel, Ralph Parchment, Patricia Lorusso, Philip A. Philip

Journal:

Investigational New Drugs

Year:

2006

Language:

english

File:

PDF, 177 KB

english, 2006

38

Phase II trial of fenretinide in advanced renal carcinoma

Ulka Vaishampayan, Lance K. Heilbrun, Ralph E. Parchment, Vikash Jain, James Zwiebel, Ramesh R. Boinpally, Patricia LoRusso, Maha Hussain

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 219 KB

english, 2005

39

A phase 1 trial of XK469: Toxicity profile of a selective topoisomerase IIβ inhibitor

Amin M. Alousi, Ramesh Boinpally, Richard Wiegand, Ralph Parchment, Shirish Gadgeel, Lance K. Heilbrun, Antionette J. Wozniak, Pamela DeLuca, Patricia M. LoRusso

Journal:

Investigational New Drugs

Year:

2007

Language:

english

File:

PDF, 380 KB

english, 2007

40

A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors

Elisabeth I. Heath, Keith Bible, Robert E. Martell, Daniel C. Adelman, Patricia M. LoRusso

Journal:

Investigational New Drugs

Year:

2008

Language:

english

File:

PDF, 158 KB

english, 2008

41

Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors

Patricia M. LoRusso, Shirish M. Gadgeel, Antoinette Wozniak, Alan J. Barge, Helen K. Jones, Zachary S. DelProposto, Pamela A. DeLuca, Jeffrey L. Evelhoch, Scott A. Boerner, Catherine Wheeler

Journal:

Investigational New Drugs

Year:

2008

Language:

english

File:

PDF, 215 KB

english, 2008

42

Phase I dose-escalation study of the thioxanthone SR271425 administered intravenously once every 3

Priscila H. Goncalves, Francine High, Paul Juniewicz, Gareth Shackleton, Jing Li, Scott Boerner, Patricia M. LoRusso

Journal:

Investigational New Drugs

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

43

Effect of coadministration of ketoconazole, a strong CYP3A4 inhibitor, on pharmacokinetics and tolerability of motesanib diphosphate (AMG 706) in patients with advanced solid tumors

Patricia LoRusso, Elisabeth I. Heath, Jesse McGreivy, Yu-Nien Sun, Rebeca Melara, Lucy Yan, Lisa Malburg, Megan Ingram, Jeffrey Wiezorek, Li Chen, Mary Jo Pilat

Journal:

Investigational New Drugs

Year:

2008

Language:

english

File:

PDF, 181 KB

english, 2008

44

A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors

Howard A. Burris, Suzanne F. Jones, Daphne D. Williams, Steven J. Kathman, Jeffrey P. Hodge, Lini Pandite, Peter T. C. Ho, Scott A. Boerner, Patricia LoRusso

Journal:

Investigational New Drugs

Year:

2011

Language:

english

File:

PDF, 167 KB

english, 2011

45

Cediranib in combination with various anticancer regimens: results of a phase I multi-cohort study

Patricia LoRusso, Anthony F. Shields, Shirish Gadgeel, Ulka Vaishampayan, Tina Guthrie, Thomas Puchalski, John Xu, Qi Liu

Journal:

Investigational New Drugs

Year:

2011

Language:

english

File:

PDF, 412 KB

english, 2011

46

A phase 1 study of BMS-275183, a novel oral analogue of paclitaxel given on a daily schedule to patients with advanced malignancies

Elisabeth I. Heath, Patricia LoRusso, Suresh S. Ramalingam, Ahmad Awada, Merrill J. Egorin, Tatiana Besse-Hamer, Fatima Cardoso, Manuel Valdivieso, Teresa Has, Leila Alland, Xiaofei Zhou, Chandra P. B

Journal:

Investigational New Drugs

Year:

2011

Language:

english

File:

PDF, 101 KB

english, 2011

47

Phase I study of oral irinotecan as a single-agent and given sequentially with capecitabine

Laura W. Goff, Al B. Benson, Patricia M. LoRusso, Antoinette R. Tan, Jordan D. Berlin, Louis J. Denis, Rebecca J. Benner, Donghua Yin, Mace L. Rothenberg

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 188 KB

english, 2012

48

A Comparison of the pharmacokinetics of the anticancer MET inhibitor foretinib free base tablet formulation to bisphosphate salt capsule formulation in patients with solid tumors

Aung Naing, Razelle Kurzrock, Laurel M. Adams, Joseph F. Kleha, Kevin H. Laubscher, Peter L. Bonate, Steven Weller, Colleen Fitzgerald, Yanmei Xu, Patricia M. LoRusso

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 163 KB

english, 2012

49

Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs

Shin Ogita, Patricia LoRusso

Journal:

Targeted Oncology

Year:

2011

Language:

english

File:

PDF, 340 KB

english, 2011

50

Vascular targeting agents

Mary Jo Pilat, Julie McCormick, Patricia Mucci LoRusso

Journal:

Current Oncology Reports

Year:

2004

Language:

english

File:

PDF, 397 KB

english, 2004

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